Dr. Mark Wardle MB BCh MD FRCP

Employment / roles

Past employment

Qualifications and prizes

  • NHS Wales Awards Winner 2019 - South East Wales MND network
  • Founding Fellow, Faculty of Clinical Informatics, 2018-
  • Fellowship of the Royal College of Physicians, 2015-
  • Doctorate of Medicine, Cardiff University, 2009 - Cerebellar ataxia: A clinical and genetic study in South Wales
  • Sir Charles Symonds Prize, Association of British Neurologists, Best Platform Presentation, 2007
  • Membership of the Royal College of Physicians, 2004
  • MB BCh, University of Wales College of Medicine, 1999
  • Elizabeth Pipe Prize in Paediatrics, 1999

Grants

  • Gray L et al. NIHSCR Wales BRAIN unit, £1,499,910 July 2015-
  • Bisson J et al. Biobanking Research support, NIHSCR AHSC, £130,322, Apr 2012-Mar 2015

Roles and responsibilities

Clinical

  • General neurology, University Hospital Wales and Prince Charles Hospital 2011-
    • Two clinics per week
    • Two ward referral sessions per week
    • On-call for neurology and stroke thrombolysis
  • Specialist ataxia and movement disorders clinic, Cardiff and Vale 2011-
    • One clinic per week
  • Specialist motor neurone disease clinic: Prince Charles Hospital 2012-
    • One clinic per month
  • Clinical lead for IT for Welsh Clinical Portal project, Cardiff and Vale 2011-2015
  • Educational and clinical supervisor, Wales Deanery 2011-
  • Medical expert for Court of Protection, December 2015

Non-clinical

  • Shortlisting and judge, COVID-19 digital solutions fund, 2020
  • Member, “Digital transformation panel”, Welsh Assembly Government, 2018 (“System reboot” report)
  • Designer and clinical lead for COM2 project, Cardiff and Vale University Health Board providing outpatient management and SNOMED CT functionality
  • Shortlisting and judge, Intel AI grant, 2019
  • NHS Wales Architecture Review Advisory Group, 2019
  • Interviewed by Wired magazine on privacy and artificial intelligence in healthcare
  • Member, Clinical Content subcommittee, Apperta Foundation, 2017-2018
  • Member, “Once for Wales” Task and Finish Group, Welsh Assembly Government, 2017-2018
  • Information standards, Task and finish group, 2016-2017.
  • Member, Welsh Clinical Informatics Council, NHS Wales Informatics Service, 2015-
  • Co-director, South Wales Motor Neurone Disease Network, 2015-
  • National UK MND register steering group, 2015-
  • Clinical databases lead, NISCHR BRAIN unit, 2015-
  • Association of British Neurologists Neurogenetics Advisory Group, 2015-2018
  • Wales Neuromuscular network steering group, 2013-
  • Medical Schools Council Assessment Alliance (MSA-AA) reference group 2012-2016
  • Ataxia UK, medical advisory panel, 2012-
  • Clinical advisor, Welsh Neurosciences Research Tissue Bank (WNRTB), 2012-

My own software projects

I currently write software using:

  • Clojure, Clojurescript, Go, Swift, Java, R, SQL, HTML/XML/CSS, LaTeX

I have previously written code using:

  • Perl, Objective-C, C, 680x0, 6502

Projects

  • go-terminology: A comprehensive terminology server. Running live and in production in NHS Wales.
  • PatientCare EPR: An electronic health record used across Wales with integrations across multiple NHS systems, used for specialist services such as multiple sclerosis, Parkinson’s disease, motor neurone disease, neuro-rehabilitation and others. Combines clinical and research cohorts using finely-grained access controls and had used my own java-based terminology server to provide SNOMED CT functionality since 2009. Over 500 users, over 30,000 patients and over 400,000 clinical encounters recorded with structured data and SNOMED CT. It underpins much of the research listed below.
  • HealthContact: iPad and iPhone application suite providing patient access to the PatientCare EPR for recording patient reported outcome measures.
  • concierge: A set of APIs implemented in golang providing access to live NHS Wales systems with identifier resolution and mapping.
  • clods: A clojure-based organisation data services API.
  • patientcare-ward: Proof-of-concept electronic observations and dynamically created NEWS chart, written in Clojurescript

Publications and abstracts

Publications

  • K Harding, V Anderson, O Williams, M Willis, S Butterworth, E Tallantyre et al A contemporary study of mortality in the multiple sclerosis population of south east Wales. Multiple sclerosis and related disorders 25, 186-191

  • M Kopczynska, WM Zelek, S Vespa et al. Complement System Biomarkers in Epilepsy. Seizure-European Journal of Epilepsy 2018

  • MO Alsaeed, KE Harding, OH Williams, MD Willis, J Hrastelj et al. Multiple sclerosis: Long‐term outcomes in ethnic minorities with MS: analysis of a UK population‐based registry. European Journal of Neurology 1 2018

  • van de Zande NA, Massey TH, McLauchlan D, Pryce-Roberts A, Zutt R, Wardle M, Payne G, Clenaghan C, Tijssen MAJ, Rosser AE, Peall KJ. Clinical Characterisation of Dystonia in Patients with Huntington’s Disease. Eur J Neurol, 2017 [in press]

  • Harding K, Tilling K, MacIver C, Willis M, Joseph F, Ingram G, Hirst C, Wardle M, Pickersgill TP, Robertson NP. Seasonal variation in multiple sclerosis relapse. J Neurol, 2017. doi:10.1007/s00415-017-8485-0

  • Wardle M and Spencer A. Implementation of SNOMED CT in an online clinical database. Future Hosp J June 1, 2017 vol. 4 no. 2 126-130.

  • Williams OH, Harding K, Rimmer A et al. Disease Modifying Treatments in MS: Clinical Outcomes of Induction and Escalation Strategies. MULTIPLE SCLEROSIS JOURNAL 2017:23 (2), 316-316.

  • Harding KH, Williams OH, Willis MD et al. Socioeconomic Status and Disability in Multiple Sclerosis. MULTIPLE SCLEROSIS JOURNAL 23 (2), 322-322.

  • Willis MD, Harding KE, Pickersgill TP, Wardle M, Pearson OR, Scolding NJ, Smee J, Robertson NP. Alemtuzumab for multiple sclerosis: Long term follow-up in a multi-centre cohort. Mult Scler. 2016 Aug;22(9):1215-23. doi: 10.1177/1352458515614092.

  • Wardle M, Sadler M How to set up a clinical database Practical Neurology 2016;16:70-74.

  • Tallantyre EC, Wardle M, Robertson NP How to run a multiple sclerosis relapse clinic Practical Neurology 2016;16:62-69.

  • Willis MD, Harding KE, Wardle M et al Site-specific clinical disease onset in multiple sclerosis. Eur J Neurol. 2015 Apr;22(4):732-5. doi: 10.1111/ene.12564. Epub 2014 Sep 8.

  • Peall KJ, Kurian MA, Wardle M et al. SGCE and myoclonus dystonia: motor characteristics, diagnostic criteria and clinical predictors of genotype. J Neurol. 2014 Dec;261(12):2296-304. doi: 10.1007/s00415-014-7488-3. Epub 2014 Sep 11.

  • Harding KE, Wardle M, Moore P, Tomassini V, Pickersgill T, Ben-Shlomo Y, Robertson NP (2014). Modelling the natural history of primary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry. 2014 May 14. pii: jnnp-2014-307791.

  • Peall KJ, Smith DJ, Kurian MA, Wardle M et al SGCE mutations cause psychiatric disorders: clinical and genetic characterization. Brain. 2013 Jan;136(Pt 1):294-303.

  • Moore P, Harding KE, Clarkson H, Pickersgill TP, Wardle M, Robertson NP (2013). Demographic and clinical factors associated with changes in employment in multiple sclerosis. Mult Scler. 2013 Oct;19(12):1647-54.

  • Fawcett K, Mehrabian M, Liu YT, Hamed S, Elahi E, Revesz T, Koutsis G, Herscheson J, Schottlaender L, Wardle M, Morrison PJ, Morris HR, Giunti P, Wood N, Houlden H (2013) “The frequency of spinocerebellar ataxia type 23 in a UK population.” J Neurol. 2013 Mar;260(3):856-9. doi: 10.1007/s00415-012-6721-1. Epub 2012 Oct 30. Erratum in: J Neurol. 2013 Mar;260(3):860.

  • Harding KE, Liang K, Cossburn MD, Ingram G, Hirst CL, Pickersgill TP, Te Water Naude J, Wardle M, Ben-Shlomo Y, Robertson NP (2013) “Long-term outcome of paediatric-onset multiple sclerosis: a population-based study.” J Neurol Neurosurg Psychiatry. 2013 Feb;84(2):141-7. doi: 10.1136/jnnp-2012-303996. Epub 2012 Nov 15.

  • Becker EB, Zuliani L, Pettingill R, Lang B, Waters P, Dulneva A, Sobott F, Wardle M, Graus F, Bataller L, Robertson NP, Vincent A (2012) “Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia.” J Neurol Neurosurg Psychiatry. 2012 Apr;83(4):437-40. doi: 10.1136/jnnp-2011-301506. Epub 2012 Feb 15.

  • Wardle, M.; Morris H.; Robertson, N. (2009), ‘Clinical and genetic characteristics of non-Asian dentatorubral pallidoluysian atrophy: A systematic review’. Mov Disord 24(11):1636-40.

  • Wardle, M. (2009), ‘Cerebellar ataxia: A clinical and genetic study in South Wales’, MD thesis, Cardiff University.

  • Wardle, M.; Majounie, E.; Muzaimi, M.; Williams, N.; Morris, H. & Robertson, N. (2009), ‘The genetic aetiology of chronic progressive cerebellar ataxia: a population-based study’, J Neurol 256 (3):343-8. Epub 2009 Mar 6.

  • Wardle, M.; Majounie, E.; Williams, N.; Rosser, A.; Morris, H. & Robertson, N. (2008), ‘Dentatorubral pallidoluysian atrophy in South Wales’, J Neurol Neurosurg Psychiatry 79, 804-807.

  • Majounie, E.; Wardle, M.; Muzaimi, M.; Cross, W.; Robertson, N. P.; Williams, N. & Morris, H. (2007), ‘Case control analysis of repeat expansion size in ataxia.’, Neurosci Lett 429, 28-32.

  • Wardle, M. & Robertson, N. (2007), ‘Progressive late-onset cerebellar ataxia’, ACNR 7, 6-12. 


Published abstracts

  • K Harding, E Kingwell, M Wardle, F Zhu, N Robertson, H Tremlett Socioeconomic status and progression of disability in MS J Neurol Neurosurg Psychiatry 2018 89 (10), A21-A21

  • M Alsaeed, K Harding, M Willis, E Tallantyre, M Wardle, T Pickersgill et al. Poster 1151: Ethnic minority outcomes in multiple sclerosis J Neurol Neurosurg Psychiatry 2017;88 (Suppl 1), A2-A2

  • WO Pickrell, S Ahmed, SF Halpin, M Wardle, K Hamandi. Poster 0018 Two cases of subarachnoid haemorrhage caused by venous sinus thrombosis J Neurol Neurosurg Psychiatry 2017; 88 (Suppl 1), A17-A17

  • B. Mohamed, E.L. Lane, E.C. Thomas, M. Landwehr, C.W. Ngu, J. Butler, K. Williams, M. Wardle. iPad-based preassessment questionnaires are feasible in a Parkinson’s service [abstract]. Mov Disord. 2016; 31 (suppl 2).

  • Harding K, Williams O, Willis M, Wardle M, Pickersgill T, Robertson NP. CONTEMPORARY ANALYSIS OF MORTALITY IN MULTIPLE SCLEROSIS J Neurol Neurosurg Psychiatry 2016;87:e1.

  • Healy S, Nasser T, Willis M, et al THYROID AUTOIMMUNITY FOLLOWING ALEMTUZUMAB TREATMENT FOR MS J Neurol Neurosurg Psychiatry 2016;87:e1.

  • DISEASE MODIFYING TREATMENTS IN MS: INDUCTION OR ESCALATION? Owain H Williams, Katharine E Harding, Mark Willis, Trevor Pickersgill, Mark Wardle, Neil P Robertson J Neurol Neurosurg Psychiatry 2015;86:11 e4 doi:10.1136/jnnp-2015-312379.29

  • DISEASE MODIFYING TREATMENT UTILISATION IN MULTIPLE SCLEROSIS Owain H Williams, Katharine E Harding, Mark Willis, Trevor Pickersgill, Mark Wardle, Neil P Robertson. J Neurol Neurosurg Psychiatry 2015;86:11 e4 doi:10.1136/jnnp-2015-312379.125

  • Clinical characteristics and genetic testing of a Huntingtin mutation negative cohort [abstract]. Peall, K.J., Morris, H.R., Wardle, M.; Movement Disorders 2015;30 Suppl 1 :362

  • FACTORS ASSOCIATED WITH EMERGENCY ATTENDANCES FOR EPILEPSY Lynch EC, Lacey AS, Pickrell WO, Smith PEM, Wardle M. J Neurol Neurosurg Psychiatry 2014;85:10. doi:10.1136/jnnp-2014-309236.73

  • NO TEMPORAL EFFECT ON DISABILITY IN MULTIPLE SCLEROSIS Katharine Harding, Mark Willis, Mark Wardle, Trevor Pickersgill, Neil Robertson J Neurol Neurosurg Psychiatry 2014;85:10 e4 doi:10.1136/jnnp-2014-309236.10

  • ALEMTUZUMAB: LONG TERM FOLLOW-UP IN A SINGLE CENTRE COHORT Mark Willis, Katharine Harding, Mark Wardle et al. J Neurol Neurosurg Psychiatry 2014;85:10 e4 doi:10.1136/jnnp-2014-309236.8

  • LATE–ONSET MULTIPLE SCLEROSIS IN SOUTH–EAST WALES Katharine Harding, Megan Griffiths, Mark Wardle, Valentina Tomassini, Trevor Pickersgill, Neil Robertson J Neurol Neurosurg Psychiatry 2013;84:11 e2 doi:10.1136/jnnp-2013-306573.26

  • EPISTATIC EFFECTS ON THE PHENOTYPE OF MULTIPLE SCLEROSIS Harding K, Loveless S, Wardle M et al J Neurol Neurosurg Psychiatry 2013;84:11 e2

  • Neighbourhood socioeconomic status and multiple sclerosis: the impact of area level deprivation on multiple sclerosis risk frequency and disease progression Moore P, Harding K, Wardle M, Pickersgill TP, Robertson NP. Mult Scler, October 2013; vol. 19, 11 suppl: pp. 74-558.

  • ARE PSYCHIATRIC SYMPTOMS A CORE PHENOTYPE OF MYOCLONUS DYSTONIA SYNDROME CAUSED BY SGCE MUTATIONS? KJ Peall, DJ Smith, MA Kurian, M Wardle et al J Neurol Neurosurg Psychiatry 2013;84:9 e1 doi:10.1136/jnnp-2013-306103.24

  • IL-7, IL-9 and IL-12 are associated with current aspects of disease, but do not predict disease course in multiple sclerosis Harding, KE; Cossburn, MD; Moore, P; Pickersgill, TP; Wardle, M; Robertson, NP. MULTIPLE SCLEROSIS JOURNAL 18;117-117 Supplement: 4.OCT 2012

  • Acute Stroke Thrombolysis-a Welsh centre’s perspective QTH Anjum, HGM Shetty, A Reed, TAT Hughes, PE Smith, T Pickersgill et al CEREBROVASCULAR DISEASES 35, 676-676

  • DO AGE AT ONSET OR GENDER AFFECT ACCUMULATION OF DISABILITY IN PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS? K Harding, L Curzon, P Moore, MD Cossburn, G Ingram, TP Pickersgill, M Wardle, NP Robertson J Neurol Neurosurg Psychiatry 2012;83:Suppl 2 A35

  • REVERSIBLE CEREBRAL VASOCONSTRICTION SYNDROME AS A CAUSE OF SUBARACHNOID HAEMORRHAGE K Ali, Y Joshi, S Halpin, M Wardle J Neurol Neurosurg Psychiatry 2012;83:Suppl 2 A1 doi:10.1136/jnnp-2012-304200a.1

  • ‘Late onset cerebellar ataxia: natural history and prognosis’, Wardle, M.; Muzaimi, M.; Robertson, N. J Neurol Neurosurg Psychiatry 2008 80,97-128

  • ‘DRPLA in South Wales’, Wardle, M.; Majounie, E.; Williams, N.; Rosser, A.; Morris, H. & Robertson, N. J Neurol Neurosurg Psychiatry 2007;78, 1014-1038.